The Amazing Spiderman #339 NM
"The Killing Cure" The Return of the Sinister Six Part 6 of 6. Script by David Michelinie. Pencils by Erik Larsen. Inks by Mike Machlan, Randy Emberlin, John Romita Sr., and Keith Williams. Cover by Erik Larsen and Hilary Barta. To Spider-Man's chagrin, Cordco's satellite launches into the stratosphere with Doc Ock's deadly poison onboard! Oh no, does this mean the Earth is doomed? Not exactly. Because the six-armed doctor's poison is actually just a cure for cocaine addiction! Otto Octavius' master plan is simply to extort rich addicts who have to keep using! But the poison has the side effect of destroying the ozone layer! And only Peter Parker and his labmates at ESU can save the planet now! Meanwhile at the TV studio across town, Mary Jane finds herself in a smaller scale life and death struggle vs. Jonathan Caesar! And only one of them will survive! Final appearance of Jonathan Caesar. Cameo appearances by the Sandman and Thor.